Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Iron (from Ionic Plant Based Minerals)
2 mg
10%
HSO Probiotic Blend (5 Billion CFU)¹Saccharomyces boulardii, Organic Barley Grass², Organic Oat Grass², Lactobacillus plantarum, Bacillus subtilis, Bifidobacterium lactis, Bifidobacterium bifidum, Lactobacillus rhamnosus, Bifidobacterium breve, Lactobacillus casei, Lactobacillus salivarius, Lactobacillus acidophilus, Lactobacillus brevis, Bifidobacterium longum, Lactobacillus paracasei
410 mg
+
Ionic Plant Based Minerals
290 mg
+
Top Medical Research Studies
9
L. plantarum reduces heart disease risk
We set out to explore the effects of Lactobacillus plantarum ATCC 14917 on heart disease in ApoE-deficient mice. Over 12 weeks, these mice were given the probiotic, and we analyzed their heart health and inflammation levels.
The results were intriguing; while L. plantarum didn’t impact body weight or overall fat levels, it did significantly reduce atherosclerotic lesions. Additionally, markers of inflammation and oxidative stress improved, suggesting this probiotic might help slow heart disease progression.
The results were intriguing; while L. plantarum didn’t impact body weight or overall fat levels, it did significantly reduce atherosclerotic lesions. Additionally, markers of inflammation and oxidative stress improved, suggesting this probiotic might help slow heart disease progression.
Read More
9
Lactobacillus plantarum reduces cholesterol
We investigated how Lactobacillus plantarum ECGC 13110402 affects cholesterol levels in a group of 49 adults with normal to mildly high cholesterol. This double-blind, placebo-controlled study showed promising results. Specifically, we observed a notable decrease in LDL cholesterol and triglycerides after 12 weeks, alongside a rise in HDL cholesterol.
Additionally, systolic blood pressure reduced significantly in participants over 60 during the study. Importantly, the probiotic was well-tolerated with no gastrointestinal side effects. Overall, this strain shows potential as a natural option to help reduce heart disease risk.
Additionally, systolic blood pressure reduced significantly in participants over 60 during the study. Importantly, the probiotic was well-tolerated with no gastrointestinal side effects. Overall, this strain shows potential as a natural option to help reduce heart disease risk.
Read More
9
Probiotic improves vascular function
We looked into whether the probiotic Lactobacillus plantarum 299v (Lp299v) can improve heart health by enhancing vascular function and reducing inflammation in men with stable coronary artery disease (CAD).
Over six weeks, twenty men consumed Lp299v, leading to improved blood vessel function and reduced levels of certain inflammatory markers.
Notably, there were no significant changes in traditional risk factors like cholesterol levels. Our findings suggest that Lp299v holds promise for heart health, particularly through its effects on gut-derived metabolites.
Over six weeks, twenty men consumed Lp299v, leading to improved blood vessel function and reduced levels of certain inflammatory markers.
Notably, there were no significant changes in traditional risk factors like cholesterol levels. Our findings suggest that Lp299v holds promise for heart health, particularly through its effects on gut-derived metabolites.
Read More
Most Useful Reviews
9
Heart burn relief
1 people found this helpful
Amazing! I have been meaning to write this review for months! I've had fantastic results using this product (Primal Defense Ultra). I suffered from severe heart burn for years and even developed an ulcer a couple of years ago. I took one capsule last Halloween, anticipating the usual discomfort from candy. To my delight, I felt near-instant relief. This product has provided what my gut needed! I highly recommend it to everyone! I haven't experienced heart burn since taking the first capsule!
Read More
9
Heart burn management
The best I have ever tried! I used to have issues with heart burn. This has been amazing!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
- All Researches
9
We investigated whether adding Lactobacillus plantarum to standard simvastatin treatment could reduce cardiovascular risk in dyslipidemic patients. In a study with 77 participants aged 40-74, we found that the combination therapy significantly lowered total cholesterol and LDL levels after 8 and 12 weeks.
The results showed not only a noteworthy decline in lipid levels but also in cardiovascular risk scores for those receiving the probiotic. This suggests that Lactobacillus plantarum may enhance heart health when used alongside traditional medications.
The results showed not only a noteworthy decline in lipid levels but also in cardiovascular risk scores for those receiving the probiotic. This suggests that Lactobacillus plantarum may enhance heart health when used alongside traditional medications.
Read More
9
L. plantarum reduces heart disease risk
We set out to explore the effects of Lactobacillus plantarum ATCC 14917 on heart disease in ApoE-deficient mice. Over 12 weeks, these mice were given the probiotic, and we analyzed their heart health and inflammation levels.
The results were intriguing; while L. plantarum didn’t impact body weight or overall fat levels, it did significantly reduce atherosclerotic lesions. Additionally, markers of inflammation and oxidative stress improved, suggesting this probiotic might help slow heart disease progression.
The results were intriguing; while L. plantarum didn’t impact body weight or overall fat levels, it did significantly reduce atherosclerotic lesions. Additionally, markers of inflammation and oxidative stress improved, suggesting this probiotic might help slow heart disease progression.
Read More
9
Probiotic improves vascular function
We looked into whether the probiotic Lactobacillus plantarum 299v (Lp299v) can improve heart health by enhancing vascular function and reducing inflammation in men with stable coronary artery disease (CAD).
Over six weeks, twenty men consumed Lp299v, leading to improved blood vessel function and reduced levels of certain inflammatory markers.
Notably, there were no significant changes in traditional risk factors like cholesterol levels. Our findings suggest that Lp299v holds promise for heart health, particularly through its effects on gut-derived metabolites.
Over six weeks, twenty men consumed Lp299v, leading to improved blood vessel function and reduced levels of certain inflammatory markers.
Notably, there were no significant changes in traditional risk factors like cholesterol levels. Our findings suggest that Lp299v holds promise for heart health, particularly through its effects on gut-derived metabolites.
Read More
9
Lactobacillus plantarum reduces cholesterol
We investigated how Lactobacillus plantarum ECGC 13110402 affects cholesterol levels in a group of 49 adults with normal to mildly high cholesterol. This double-blind, placebo-controlled study showed promising results. Specifically, we observed a notable decrease in LDL cholesterol and triglycerides after 12 weeks, alongside a rise in HDL cholesterol.
Additionally, systolic blood pressure reduced significantly in participants over 60 during the study. Importantly, the probiotic was well-tolerated with no gastrointestinal side effects. Overall, this strain shows potential as a natural option to help reduce heart disease risk.
Additionally, systolic blood pressure reduced significantly in participants over 60 during the study. Importantly, the probiotic was well-tolerated with no gastrointestinal side effects. Overall, this strain shows potential as a natural option to help reduce heart disease risk.
Read More
9
We investigated whether Lactobacillus plantarum could help combat high blood pressure, a major risk factor for heart disease. By using a special strain, we were able to express angiotensin-converting enzyme inhibitory peptides and test their effects on spontaneously hypertensive rats.
Our findings were promising; after treatment, systolic blood pressure significantly decreased, and beneficial changes in important biological markers were observed, without major side effects. This suggests that Lactobacillus plantarum could be a safe and effective approach to managing hypertension and supporting heart health.
Our findings were promising; after treatment, systolic blood pressure significantly decreased, and beneficial changes in important biological markers were observed, without major side effects. This suggests that Lactobacillus plantarum could be a safe and effective approach to managing hypertension and supporting heart health.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Heart burn relief
1 people found this helpful
Amazing! I have been meaning to write this review for months! I've had fantastic results using this product (Primal Defense Ultra). I suffered from severe heart burn for years and even developed an ulcer a couple of years ago. I took one capsule last Halloween, anticipating the usual discomfort from candy. To my delight, I felt near-instant relief. This product has provided what my gut needed! I highly recommend it to everyone! I haven't experienced heart burn since taking the first capsule!
Read More
9
Heart burn management
The best I have ever tried! I used to have issues with heart burn. This has been amazing!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Tian Y, Wu G, Zhao X, Zhang H, Ren M, et al. Probiotics combined with atorvastatin administration in the treatment of hyperlipidemia: A randomized, double-blind, placebo-controlled clinical trial. Medicine (Baltimore). 2024;103:e37883. doi:10.1097/MD.0000000000037883
- Neverovskyi A, Chernyavskyi V, Shypulin V, Hvozdetska L, Tishchenko V, et al. Probiotic Lactobacillus plantarum may reduce cardiovascular risk: An experimental study. ARYA Atheroscler. 2021;17:1. doi:10.22122/arya.v17i0.2156
- Aboulgheit A, Karbasiafshar C, Zhang Z, Sabra M, Shi G, et al. probiotic induces Nrf2-mediated antioxidant signaling and eNOS expression resulting in improvement of myocardial diastolic function. Am J Physiol Heart Circ Physiol. 2021;321:H839. doi:10.1152/ajpheart.00278.2021
- O'Morain VL, Chan YH, Williams JO, Alotibi R, Alahmadi A, et al. The Lab4P Consortium of Probiotics Attenuates Atherosclerosis in LDL Receptor Deficient Mice Fed a High Fat Diet and Causes Plaque Stabilization by Inhibiting Inflammation and Several Pro-Atherogenic Processes. Mol Nutr Food Res. 2021;65:e2100214. doi:10.1002/mnfr.202100214
- Hofeld BC, Puppala VK, Tyagi S, Ahn KW, Anger A, et al. Lactobacillus plantarum 299v probiotic supplementation in men with stable coronary artery disease suppresses systemic inflammation. Sci Rep. 2021;11:3972. doi:10.1038/s41598-021-83252-7
- Hassan A, Din AU, Zhu Y, Zhang K, Li T, et al. Anti-atherosclerotic effects of Lactobacillus plantarum ATCC 14917 in ApoE mice through modulation of proinflammatory cytokines and oxidative stress. Appl Microbiol Biotechnol. 2020;104:6337. doi:10.1007/s00253-020-10693-x
- Malik M, Suboc TM, Tyagi S, Salzman N, Wang J, et al. Lactobacillus plantarum 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease. Circ Res. 2018;123:1091. doi:10.1161/CIRCRESAHA.118.313565
- Martinic A, Barouei J, Bendiks Z, Mishchuk D, Heeney DD, et al. Supplementation of Lactobacillus plantarum Improves Markers of Metabolic Dysfunction Induced by a High Fat Diet. J Proteome Res. 2018;17:2790. doi:10.1021/acs.jproteome.8b00282
- Costabile A, Buttarazzi I, Kolida S, Quercia S, Baldini J, et al. An in vivo assessment of the cholesterol-lowering efficacy of Lactobacillus plantarum ECGC 13110402 in normal to mildly hypercholesterolaemic adults. PLoS One. 2017;12:e0187964. doi:10.1371/journal.pone.0187964
- Yang G, Jiang Y, Yang W, Du F, Yao Y, et al. Effective treatment of hypertension by recombinant Lactobacillus plantarum expressing angiotensin converting enzyme inhibitory peptide. Microb Cell Fact. 2015;14:202. doi:10.1186/s12934-015-0394-2
- Mirjani R, Faramarzi MA, Sharifzadeh M, Setayesh N, Khoshayand MR, et al. Biosynthesis of tellurium nanoparticles by Lactobacillus plantarum and the effect of nanoparticle-enriched probiotics on the lipid profiles of mice. IET Nanobiotechnol. 2015;9:300. doi:10.1049/iet-nbt.2014.0057
- Ahrén IL, Xu J, Önning G, Olsson C, Ahrné S, et al. Antihypertensive activity of blueberries fermented by Lactobacillus plantarum DSM 15313 and effects on the gut microbiota in healthy rats. Clin Nutr. 2015;34:719. doi:10.1016/j.clnu.2014.08.009
- Barreto FM, Colado Simão AN, Morimoto HK, Batisti Lozovoy MA, Dichi I, et al. Beneficial effects of Lactobacillus plantarum on glycemia and homocysteine levels in postmenopausal women with metabolic syndrome. Nutrition. 2014;30:939. doi:10.1016/j.nut.2013.12.004
- Gorenjak M, Gradišnik L, Trapečar M, Pistello M, Kozmus CP, et al. Improvement of lipid profile by probiotic/protective cultures: study in a non-carcinogenic small intestinal cell model. New Microbiol. 2014;37:51.
- Huang Y, Wang X, Wang J, Wu F, Sui Y, et al. Lactobacillus plantarum strains as potential probiotic cultures with cholesterol-lowering activity. J Dairy Sci. 2013;96:2746. doi:10.3168/jds.2012-6123
- Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, et al. Intestinal microbiota determine severity of myocardial infarction in rats. FASEB J. 2012;26:1727. doi:10.1096/fj.11-197921
